ABSTRACT
Objective:To evaluate the efficacy of Dihuang-Yinzi Decoction combined with donepezil hydrochloride in the treatment of mild to moderate Alzheimer's disease (AD). Methods:114 patients with mild to moderate AD in the First Hospital of Yulin in Suide District from February 2017 to February 2019 were divided into two groups according to the method of random number table, with 57 cases in each group. The control group took donepezil hydrochloride tablets orally, and the study group took Dihuang-Yinzi Decoction based on the control group. Both groups were treated continuously for 3 months. The activities of daily living scale (ADL), Mini-Mental State Examination (MMSE) and the Alzheimer’s disease assessment scale-cognitive section (ADAS-cog) were used to evaluate the life ability and cognitive function of patients. The concentrations of Notch 1 signaling protein, a disintegrin and metalloproteinase 10 (ADAM10) and β-amyloid precursor protein endonuclease 1 (BACE1) in serum were detected by Western blot. The levels of acrolein were detected by ELISA, the adverse reactions during the treatment were recorded, and the clinical efficacy was evaluated. Results:The total effective rate was 84.2% (48/57) in the study group and 64.9% (37/57) in the control group. The difference between the two groups was statistically significant ( χ2=5.596, P=0.018). After the treatment, the ADL and ADAS-cog scores of the study group were lower than those of the control group ( t values were 5.939, 6.124, respectively, all Ps<0.01), and MMSE scores were higher than that of the control group ( t=6.087, P<0.01). The levels of Notch1 signaling protein (3.43 ± 0.58 vs. 1.31 ± 0.47, t=21.440) and ADAM10 (1.86 ± 0.23 vs. 1.12 ± 0.25, t=16.446) in the study group were higher than those of the control group ( P<0.01), and the levels of BACE1 (0.62 ± 0.15 vs. 0.98 ± 0.17, t=11.988) and acrolein (2.19 ± 0.39 nmol/mg vs. 4.76 ± 0.54 nmol/mg, t=12.354) were lower than those of the control group ( P<0.01). The adverse reaction rate was 14.7% (11/57) in the study group and 14.0% (8/57) in the control group, and there was no significant difference between the two groups ( χ2=0.568, P=0.451). Conclusions:Dihuang-Yinzi Decoction combined with donepezil hydrochloride tablets can effectively improve the cognitive function and life ability of patients with mild to moderate AD, with clinical efficacy.
ABSTRACT
Objective To explore the effect and application value of retinal photocoagulant combined with compound anisodine in the treatment of diabetic retinopathy , and its effect on vascular endothelial growth factor (VEGF) and insulin-like growth factor-1(IGF-1) level.Methods 116 patients with diabetic retinopathy were selected ,and they were randomly divided into observation group and control group according to the digital table ,58 cases in each group .The control group was given retinal photocoagulation treatment , and the observation group was given retinal photocoagulation combined with compound anisodine treatment .The therapeutic effect was compared between the two groups.Results The total effective rate of the observation group was 93.10％,which was significantly higher than 77.59％ of the control group, and the difference between the two groups was statistically significant (χ2 =5.582,P<0.05).The edema absorption time,bleeding absorption time,exudate absorption time of the observation group were (4.19 ±1.24) d,(2.19 ±1.01) d,(9.48 ±2.13) d,respectively,which of the control group were (5.83 ±2.85)d,(3.25 ±1.88)d,(13.54 ±3.88)d,respectively,and the differences between the two groups were statistically significant (t=4.018,3.782,6.985,all P<0.05).After treatment,the VEGF and IGF-1 levels in the observation group were (85.12 ±4.64) ng/L,(90.17 ±4.95)μg/L,respectively,which in the control group were (100.48 ±9.26)ng/L,(132.69 ±10.04)μg/L,respectively,the differences between the two groups were statistically significant (t=11.294,28.928,all P<0.05).Conclusion Retinal photocoagulation surgery combined with compound anisodine in the treatment of diabetic retinopathy can improve clinical curative effect ,promote the patients'visual acui-ty,adjust the concentration of VEGF ,the effect is remarkable ,it is worthy of popularizing in clinical application .
ABSTRACT
Objective To investigate the safety of argon plasma coagulation (APC) with submucosal injection for colon polyps.Methods A total of 30 sets of fresh sigmoid colon from healthy pigs were assigned to control group to receive direct APC,and to treatment group to receive APC with submucosal injection,respectively.After same time and energy of APC,each specimen was sampled for pathological evaluation and the damage extent was determined as mucosa,submucosa (superior 1/3,middle1/3,inferior 1/3),and muscularis propria.Ten cases of colon sessile polyps with diameter of about 1-2 cm,elevated within 3mm by endoscopic ultrasonography(EUS).Direct APC or APC with submucosal injection were performed,respectively,and the difference was observed by EUS.Results In 30 cases of control group,the injury depth of 5 cases reached to the muscularis propria and of 25 cases to submucosa layer,among which 4 cases showed damage to superior submucosa 12 middle submucosa and 9 inferior submucosa.In 30 cases of treatment group,there was no damage to muscularis propria.The injury depth of 26 cases reached submucosa layer,among which 22 cases showed damage to superior submucosa,4 middle submucosa.The results showed significant difference between two groups (P ＜0.01).In patients who underwent APC with submucosal injection,EUS showed effective isolation of mucosa and muscularis propria.It confined the injury to the mucosal layer.Without treatment of submucosal injection in advance,it seemed easier to damage the submucosa and muscularis propria.Conclusion Submucosal injection can protect the colon injured by APC,and may reduce the risk of colon perforation by APC for colon polyps.